Abrams' Clinical Drug Therapy: Rationales for Nursing by Sandra Smith, Geralyn Frandsen

By Sandra Smith, Geralyn Frandsen

This well known center nursing pharmacology textbook presents distinct assurance of nursing interventions for drug remedy with similar rationales. hugely praised for its geared up and readable presentation, the textual content explains the "why" at the back of each one nursing motion, and emphasizes how medications paintings another way in numerous sufferers. The tenth variation has a brand new clean layout and process with an additional concentrate on sufferer security built-in into the textual content.

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Sodium and potassium) use this pathway, but their movement is regulated by specific channels with a gating mechanism (a flap of protein that opens briefly to allow ion movement and then closes). The third pathway involves carrier proteins that transport molecules from one side of the cell membrane to the other. All of the carrier proteins are selective in the substances they transport; a drug’s chemical structure determines which carrier will transport it. indd 19 Excretion (eg, kidney, expired air, sweat, feces) Mechanisms Once absorbed into the body, drugs are transported to and from target cells by passive diffusion, facilitated diffusion, and active transport.

Receptors are dynamic cellular components that can be synthesized by body cells and altered by endogenous substances and exogenous drugs. For example, prolonged stimulation of body cells with an excitatory agonist usually reduces the number or sensitivity of receptors. As a result, the cell becomes less responsive to the agonist (a process called receptor desensitization or down-regulation). Prolonged inhibition of normal cellular functions with an antagonist may increase receptor number or sensitivity.

The cytoplasm surrounds the nucleus and contains the working units of the cell. The cytosol, the clear fluid portion of the cytoplasm, contains dissolved proteins, electrolytes, and glucose. The endoplasmic reticulum (ER) contains ribosomes, which synthesize proteins, including enzymes that synthesize glycogen, triglycerides, and steroids and those that metabolize drugs and other chemicals. The ER is also important in the production of hormones by glandular cells and the production of plasma proteins by liver cells.

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