Adalat: A Comprehensive Review by P. R. Lichtlen (auth.), Professor Dr. P. R. Lichtlen,

By P. R. Lichtlen (auth.), Professor Dr. P. R. Lichtlen, Professor Dr. A. Reale (eds.)

As little as 30 years in the past, cardiovascular learn at Bayer used to be only a small sideline with in an atmosphere ruled by way of chemotherapy study, and in basic terms 15 years in the past, Bayer's pharmaceutical company used to be restricted to ecu and Latin Ameri­ can nations, with revenues in cardiovascular prescribed drugs with reference to 0. It is going with out asserting that Adalat has replaced the corporate as an entire in its learn, improvement, and advertising, either in Germany and, most significantly, global­ extensive. In learn and improvement, Adalat has led the way in which in to new components reminiscent of high blood pressure, acute neurology, dementia, atherosclerosis, and center failure. In pharmacology, Adalat used to be current on the dawning of the second one phar­ macological revolution, which began from entire animal versions and progres­ sed, through in vitro screening and pharmacological examine at the DHP receptor, all the way down to the molecular point with the cloning of calcium-channel proteins. Having the Adalat tale heavily in its early years as a bench scientist, allow me take this chance to thank the inventors, the scientists, and the investigators who've helped to faucet the extensive power of calcium-channel blockade with dihyd­ ropyridines typically and Adalat particularly. yet, luck are usually not imprecise our imaginative and prescient. there's no cause of us to relaxation on our laurels: it's going to take actual thoughts in cardiovascular learn to most sensible the greatest set by way of Adalat. allow us to take in the challenge.

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It was largely due to close cooperation between clinical research and marketing that this message was communicated on an international scale and successfully realized in terms of practical medicine. Marketing managed convincingly to bring across the results of research as a clear message. The first imperative was to communicate these new discoveries about calcium antagonists. Practising doctors had heard nothing about them in their training. The first job was to present the new ideas on pathophysiology skillfully and clearly so that this theoretical advance would be reflected in actual prescribing-habits.

The first job was to present the new ideas on pathophysiology skillfully and clearly so that this theoretical advance would be reflected in actual prescribing-habits. This meant that Bayer Marketing first had to get to know the cardiovascular scene in depth, a field in which the company had scarcely been involved until then. In other words, cardiovascular marketing practically had to start from scratch, working in the researchers to give the product a profile in the company and in clinical practice.

Circulation 59: 1056-1062 8. Pedersen OL (1978) Does verapamil have a clinically significant antihypertensive effect? Eur J Clin Pharmacol13:21-24 9. Kiowski W, Bolli MD, Erne P, Miiller FB, Hulthen UL, Biihler FR (1989) Mechanisms of action and clinical use of calcium antagonists in hypertension. Circulation 80 [Suppl. VI]: IV-136-IV-144 10. Frishman WH, Garofalo JL, Rothschild A, Rothschild M, Greenberg SM, Soberman J (1989) The nifedipine gastrointestinal therapeutic system in the treatment of hypertension.

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