By George Klein, Sidney Weinhouse, Alexander Haddow (Eds.)
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The advantage of multiple over single sites of immunization, even when the total number of irradiated tumor cells used is the same, was also apparent from experiments (Parr, 1970) involving the arrest of mouse lymphomas. In one of the tumors, a n effect was only seen following multiple immunization, and a single immunization failed t o arrest the growth of even a very small innoculum of 100 cells. I n the studies of human malignant melanoma to which reference has already been made (see p. 281, an effect of autografting on immunity was only observed in those patients who were injected with irradiated tumor cells a t many different sites.
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