Brain damage and repair : from molecular research to by T. Herdegen, J. Delgado-Garcia

By T. Herdegen, J. Delgado-Garcia

This e-book builds a unique bridge from molecular examine to medical remedy. This method unearths the useful good points of neurons and glia within the specific context of vulnerability and self-protection, intracellular houses and extracellular matrix. bobbing up from this platform, this quantity unfolds the molecular and systemic strategies underlying migration problems, axonal damage, fix and regeneration.

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Foster, M. S. (1897). A textbook of Physiology. Part III: The central nervous system. , London: Macmillan. Henneman, E. M. (1981). Functional organisation of motoneuron pools and its inputs. In Handbook of Physiology. 1, Volume II, part 1 (Ed. M. B. 423-507. Bethesda: Maryland. American Physiological Society. Hering, H. &Sheng, M. (2001). Dendritic spines: structure, dynamics and regulation. Nature Reviews Neuroscience 2: 880-888. , Alvarez, J. & Koenig, E. (2002). Axonal and presynaptic protein synthesis: new insights into the biology of the neuron.

Large neurones tend to have round nuclei, which are located centrally within the cell body, whereas nuclear irregularity (crenation) and a peripheral location (eccentricity) are common in smaller neurones. A membranous envelope that is continuous on the cytoplasmic side with smooth and rough endoplasmic reticulum surrounds the nucleus. This envelope shows periodic attenuations termed nuclear pores. , 1991). , 1995). Reduced nuclear activity, for example in a neurone about to die, is associated with an increase in nuclear density (pyknosis).

Journal of Neuroscience, 22, 8422-8428. (2001) Localization and translation of mRNA in dendrites and axons. Nataure Reviews Neuroscience, 2, 889-898. , Kossut M. , Skangiel-Kramska J. (1997) Glutamate receptors in cortical plasticity: molecular and cellular biology. Physiological Reviews, 77, 217-255. A. ) Handbook of Chemical Neuroanatomy, vol. 19: Immediate early genes and inducible transcription factors in mapping of the central nervous system function and dysfunction. Elsevier, Amsterdam, Boston, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney, Tokyo, 2002.

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