By S.-I. Nishikawa, M. Osawa (auth.), O.D. Wiestler, B. Haendler, D. Mumberg (eds.)
This ebook describes the new advancements within the rising box of melanoma stem cells. Their attainable effect for the identity of novel remedy paradigms for melanoma are mentioned. The e-book will quite often be of curiosity to scientists and clinicians focused on melanoma learn, or to scholars wishing to go into into this area.
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Extra resources for Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy
2000), RhoB (Mazieres et al. 2004), RhoC (Ikoma et al. 2004), Rac (del Peso et al. 1997), and Cdc 42 (Yao et al. 2002) are known to be involved in lung carcinogenesis, but it is unclear how they contribute to cancer development. We can thus hypothesize that cross talk between Rho and Wnt signaling may contribute in some unspecified manner to lung tumorigenesis, particularly through the mechanisms of cell adhesion and migration (Malliri and Collard 2003). Another putative mediator of non-canonical Wnt signaling is the JNK pathway (Veeman et al.
28 28 29 30 31 35 37 37 39 40 41 42 42 44 46 47 Abstract. The Wnt signal transduction pathway plays important roles during embryo development, regulating cell proliferation and survival of immature cells. However, its improper function can lead to harmful consequences for humans, such as aberrant cell proliferation and, therefore, cancer. Increasing evidence suggests that stem cells may be the source of mutant cells that cause cancers to develop and proliferate.
1 Wnt Ligands . . . . . . . . . . . . . . 2 Wnt Antagonists . . . . . . . . . . . . . 3 Dishevelled (Dvl) . . . . . . . . . . . . 4 APC . . . . . . . . . . . . . . . . 5 β-Catenin . . . . . . . . . . . . . . 6 Non-canonical Pathway . . . . . . . . . . . 5 Potential Therapeutic Approaches Targeting the Wnt Pathway . 6 Summary . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . .