By P. Stoll, P. Stoll Jr. (auth.), Gisela Dallenbach-Hellweg (eds.)
Few matters in gynecology, not to mention in medication typically, have provoked such inter est or learn as cervical melanoma. even supposing the wealth of monographs and books post ed at the topic would appear to obviate the necessity for extra, the good advances made within the clinical sciences and in gynecological event and strategies lately demand, if now not require, a brand new publication on cervical melanoma to assemble the most recent principles and traits in its tools of research, analysis, and remedy. even supposing precancerous lesions became extra universal, the variety of ladies constructing invasive cervical carcinomas has now not elevated, owing partly to courses of sufferer schooling, partly to screening examinations backed by means of the govt.. The gynecologist is now in a position to become aware of with well-tried and proved concepts precan cerous states of the cervix, and to regard those successfully earlier than they develop into invasive melanoma. as a result, fresh pursuits in cervical melanoma have shifted from the vintage descrip tion of invasive carcinoma to more moderen stories of reason, prognosis, remedy, and terminol ogy of its precursors. because the reader will research, epidemiological experiences as publications for the longer term account for, and justifiably so, an immense a part of this e-book. New wisdom approximately alterations within the morphology of cervical carcinoma confirms its dependency on hormonal stimulation. in addition, modem studies serve to give an explanation for which treatment is better. Overlapping of ideas and reviews among a few chapters couldn't be avoided.
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Extra resources for Cervical Cancer
We use a machine staining technique. In the Zytochromat the containers are of 300 mI capacity, while the Shandon machine has containers of 400 mI. These machines have a daily capacity of 500 and 650 slides respectively. After each batch has been processed, the staining solutions, rinsing fluids, and dehydrating solutions are completely replaced by fresh materials. In laboratories handling fewer slides and performing the staining procedure at irregular intervals it may be necessary, for various reasons, to renew the staining solutions after processing a relatively small number of slides.
X 40 33 tion of cytoplasmic structures. Finally, the cell loses the power of maintaining its shape, and the cytoplasm liquefies and disappears. Degenerative changes in the nucleus present a variety of pictures, known by the terms karyolysis, karyorrhexis, and pyknosis (Fig. 9). Nuclear degeneration often begins by deposition of chromatin on the nuclear membrane, which gives the appearance of being thickened. The secretory cells of the endocervix are particularly sensitive to adverse influences.
The hematoxylin must be filtered every day to remove the oxidation layer on the surface. For the other stain solutions filtration at 2-day intervals is sufficient. To avoid evaporation or absorption of water vapor from the air the storage containers must be kept tightly closed, and the staining solutions must be stored in a cool place in the dark. Xylol tums cloudy as it becomes contaminated with water and must then be replaced. When changing the solutions it is important to clean the jars carefully so as to avoid contamination with detached cell material which has accumulated at the bottom.