Chitosan for Biomaterials II by Rangasamy Jayakumar, M. Prabaharan, Riccardo A. A.

By Rangasamy Jayakumar, M. Prabaharan, Riccardo A. A. Muzzarelli

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Chitosan and Chitosan Derivatives in Drug supply and Tissue Engineering

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Chitosan: A Promising Biomaterial for Tissue Engineering Scaffolds

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Additional resources for Chitosan for Biomaterials II

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Initially, the grafting of hydrophobic alkyl chains onto chitosan is the most straightforward way to impart amphiphilic properties to chitosan. For this purpose, alkyl aldehydes or alkyl ketones were selectively grafted onto the primary amino groups of chitosan with formation of the corresponding Schiff base [47–49]. A reduction step mediated by sodium/potassium borohydride (NaBH4/KBH4) or sodium cyanoborohydride (NaBH3CN) converted the imine group into the more stable amine with formation of the corresponding N-alkyl chitosan derivatives (Fig.

20 21 22 22 24 28 28 29 31 34 36 37 1 Introduction Polymers are extensively used for the delivery of an active pharmaceutical ingredient. They can form a matrix or membrane that can control the release of a drug over a prolonged period, thus avoiding repetitive dosing. They can also be used to form (nano)carriers to deliver drugs, in particular poorly soluble drugs or biotechnology-based drugs.

4 Biomedical Applications of Chitosan and Chitosan Derivatives . . . . . . . . . . . . . . 1 Gene Delivery by Chitosan and Chitosan Derivatives . . . . . . . . . . . . . . . . 2 Chitosan Derivatives for the Delivery of Poorly Soluble Drugs . . . . . . . . . . . 3 Chitosan and Chitosan Derivatives in Tissue Engineering . . . . . . . . . . . . . . 5 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . .

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