Colorectal Cancer in Clinical Practice: Prevention, Early by Bernard Levin, Paul Rozen, Stephen J. Spann, Graeme P. Young

By Bernard Levin, Paul Rozen, Stephen J. Spann, Graeme P. Young

The quick fee of improvement within the fields of prevention, early detection and administration for colorectal melanoma signifies that the profitable first version of this obtainable advisor has had to be up to date and revised all through. basic care physicians and experts alike will proceed to discover this an necessary synopsis of the problems and concepts.

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Extra resources for Colorectal Cancer in Clinical Practice: Prevention, Early Detection and Management, Second Edition

Example text

L-temperature cooking of meat (red or white) and fish, especially w~1en exposed to direct flame. These heteroC)1Ciic amines may undergo oxidation an,jjor acetylation and eventually b·= converted into car- cinogens that are known to induce colorectal cancer in rodents and alter DNA bases, thus inducing mutations. Oxidation, in the liver, and acetylation are under control of genetically determined enzymes. 9). <:;H? LH1, and MSH6---genes that encode the MV1R proteins-have been identified and shown to be the major causes of HNPCC (see Chapter 6).

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Although not of ,jietary origin, protect against colorectal cancer in animal models. Ds) non-steroidal anti- have a systemi·c action on oncogenesis; they may achieve this by regulating apoptosis and hence stabilizing the genome. orecta! cancer. ucosa! orecta! tumors may be part of the explanation. ned in deptl1 the relationships bet\AJeen

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