By Prof. Dr. Dres. h.c. Harald zur Hausen (auth.)
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The desmosomal anchor protein complex consisting of plakoglobin and desmoplakin serves as an anchoring site for intermediate filaments with a diameter (7 -12 nanometers) between that of actin filaments (5-6 nanometers) and that of microtubuli (20-25 nanometers). Plakoglobin is the only plaque protein occurring in both intermediate junctions and desmosomes. The epidermis (surface layer of the skin), a tissue subjected to consider- able mechanical strain, has a particularly large number of cell-to-cell contact sites.
Dr. Friedrich Marks Divisions and their heads: Pathochemistry: Prof. Dr. Volker Kinzel Biochemistry of the Cell: Prof. Dr. Dieter Werner Biochemistry of Tissue-Specific Regulation: Prof. Dr. Friedrich Marks Differentiation and Carcinogenesis in vitro: Prof. Dr. Norbert Fusenig Biochemistry of Tumors: Prof. Dr. Dietrich Keppler Molecular Biology of Mitosis: Prof. Dr. Herwig Ponstingl Project groups and their heads: Biochemical Cell Physiology: Prof. Dr. Walter Pyerin All these studies aim at deepening our knowledge of molecular processes whose disturbance results in the development and growth of tumors.
Differential Loss of E-Cadherin Expression in Infiltrating Ductal and Lobular Breast Carcinomas. American J. Pathol. : Cytoskeletal Architecture and Epithelial Differentiation: Molecular Determinants of Cell Interaction and Cytoskeletal Filament Anchorage. C. R. Acad. Sci. : Identification of the Ubiquitous Human Desmoglein, Dsg2, and the Expression Catalogue of the Desmoglein Subfamily of Desmosomal Cadherins. Exp. Cell Res. 2 Drosophila as an Animal Model System for Identifying Tumor Suppressor Genes and Analyzing Their Function by Dennis Strand, Istvan Torok, and Bernard M.