Drug and Enzyme Targeting: Part A by Nathan P. Colowick, Nathan P. Kaplan, Kenneth J. Widder,

By Nathan P. Colowick, Nathan P. Kaplan, Kenneth J. Widder, Ralph Green

The severely acclaimed laboratory common, equipment in Enzymology, is likely one of the so much hugely revered courses within the box of biochemistry. in view that 1955, every one quantity has been eagerly awaited, usually consulted, and praised through researchers and reviewers alike. The sequence includes a lot fabric nonetheless appropriate at the present time - actually a necessary booklet for researchers in all fields of lifestyles sciences.

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Additional resources for Drug and Enzyme Targeting: Part A

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BURGER, E. TOMLINSON, J. E. DE ROO, and J. PALMER Introduction Albumin microspheres are perceived as potential carriers of drugs for targeting and controlled release. Examination of the biological fate of these carriers is an essential part of their study. Apart from tedious histological and autoradiology examination, the use of gamma scintigrapby affords a most suitable means of following the kinetics of the carrier in v i v o and without recourse to invasion. 6 H o w e v e r , technetium-99m does have some advantages (for diagnostic imaging purposes) over these, including a short half-life, a detection level of 140 keV with the gamma camera, and its safety and availability.

I 20 25 FIG. I. Relative number of butadione-stabilized albumin microspheres per milligram (Nr x 10 3) versus sphere diameter (d), determined using a model z~ Coulter counter equipped with a Channelyser. Points refer to spheres produced in a nonbaffled ([3) and baffled ( 0 ) cell. 5. T A B L E III EFFECT OF MANUFACTURING VARIABLE ON THE MEAN DIAMETER OF HUMAN SERUM ALBUMIN MICROSPHERES a Factor Change Mean diameter b Oil viscosity" Oil amount Protein amount Aqueous phase J Stirring speed Surfactant e Decrease Increase Increase Increase Increase Addition Increase Increase Increase Increase Decrease No effect " From ref.

3. m average diameter. 4 82 86 92 94 using a quantitative capillary rise technique for measuring relative hydrophilicity by water wetting in a MS-packed column. , glutaraldehyde). As shown in the table, ~ PHYSIOLOGICAL SALINE -~HPLC PUMP COLUMN WITH AD-HSA/MS FRACTION -"-1 / - C O L L E C T O R ¢/ AT 4 . 0 ° FI(;. 4. Schematic of in vitro dynamic flow system for drug release. [2] HYDROPHILIC ALBUMIN MICROSPHERES 25 100 &&&&&&&&&&&&&&&&~&&a 80 BO A & & && & E "r- xxxXXXXXXXXXXXXXXXXXXXXXX 20 ' ~X X 0 X b , I 2 , 4 I 6 8 Time (hr) A I , 10 12 14 -- Fl6.

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