Prog Nucleic Acid Res V25 (v. 25) by Waldo E. (editor) Cohn

By Waldo E. (editor) Cohn

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RNA that includes the body of the RNA; d, displaced single-stranded DNA; e , rehybridized leader; f, intervening DNA sequences. have extended these studies of RNA splicing to a potentially simpler viral system, the minute virus of mice (MVM), a nondefective member of the parvovirus group. The MVM DNA molecule contains a stable hairpin duplex at its 5’ end and a 3’-terminal structure suitable for priming complementary strand synthesis in uitro (77, 78). We attempted to determine the sequence arrangement of MVM RNA by examining, in the electron microscope, hybrids formed between the abundant species of nuclear and cytoplasmic poly(A)-containing RNA and single-stranded genomic DNA (28).

W. A. Haseltine, A. M. Maxam and W. Gilbert, PNAS 74, 989 (1977). 89. J. Abelson, ARB 48, 1035 (1979). 90. R. Breathnach, C. Benoist, K. OHare, F. Cannon and P. Chambon, PNAS 75,4853 (1978). 91. M. R. Lemer, J. A. Boyle, S. M. Mount, S. L. Wolwin and J. A. Steib, Nature 283, 220 (1980). 92. B. Thimmappaya and T. Shenk,J. Virol. 30,668 (1979). 93. G. Volckaert, J. Feunteun, L. V. Crawford, P. Berg and W. Fiers,]. Virol. 30,674 ( 1979). 94. M. Bina, R. J. Feldman and R. G. Deeley, PNAS 77, 1278 (1980).

A. Cell Differentiation and Gene Activity Several models have been proposed to explain control of gene activity based on DNA methylation. The first model suggesting that DNA methylation plays a role in cell differentiation predicts transition of G . C to A T. The thymine residues produced by this deamination (called DNA minor thymine, or DMT) are expected to receive their methyl groups from methionine and to be nonrandomly distributed in the DNA. In addition, DMT should be found only in cells undergoing terminal differentiation.

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